CenBRAIN Neurotech’s New Publication in Biosensors

Titled Advanced Nanomaterials-Based Electrochemical Biosensors for Catecholamines Detection: Challenges and Trends, this contribution has been published in MDPI Biosensors. In this publication, we introduced a comprehensive overview of the recent advances in electrochemical biosensors for catecholamines neurotransmitters monitoring. Congratulations to Zina Fredj and to this paper’s co-author (Mohamad Sawan) for this excellent achievement.

Z. Fredj and M. Sawan, “Advanced Nanomaterials-Based Electrochemical Biosensors for Catecholamines Detection: Challenges and Trends,” Biosensors, vol. 13, no. 2, Art. no. 2, Feb. 2023, doi: 10.3390/bios13020211.


Catecholamines, including dopamine, epinephrine, and norepinephrine, are considered one of the most crucial subgroups of neurotransmitters in the central nervous system (CNS), in which they act at the brain’s highest levels of mental function and play key roles in neurological disorders. Accordingly, the analysis of such catecholamines in biological samples has shown a great interest in clinical and pharmaceutical importance toward the early diagnosis of neurological diseases such as Epilepsy, Parkinson, and Alzheimer diseases. As promising routes for the real-time monitoring of catecholamine neurotransmitters, optical and electrochemical biosensors have been widely adopted and perceived as a dramatically accelerating development in the last decade. Therefore, this review aims to provide a comprehensive overview on the recent advances and main challenges in catecholamines biosensors. Particular emphasis is given to electrochemical biosensors, reviewing their sensing mechanism and the unique characteristics brought by the emergence of nanotechnology. Based on specific biosensors’ performance metrics, multiple perspectives on the therapeutic use of nanomaterial for catecholamines analysis and future development trends are also summarized.

More information can be found at the following link: https://www.mdpi.com/2079-6374/13/2/211

(Simplified diagram showing electrochemical sensors/biosensors following various surface modifications for catecholamine detection. )

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