Sumin BIAN

Sumin Bian
Research Assistant Professor, started Jan. 2019
Email: biansumin@westlake.edu.cn
Ph.D. KU Leuven

Biography

Dr. Bian is currently a research assistant professor (助理研究员) in CenBRAIN at School of Engineering, Westlake University. She received the Ph.D. degree in Pharmaceutical Science from KU Leuven, Leuven, Belgium in 2018, and before that, the Master of Engineering in Nutrition and Food Safety from China Agricultural University, Beijing, China in 2014. Till now, she has published 17 SCI papers with 9 as the first author. She was a digital oral speaker for European Crohn's and Colitis Organisation (ECCO) 2017 and a recipient of United European Gastroenterology Week (UEGW) Travel Award 2016, and a receiver of the oversea doctoral scholarship from China Scholarship Council and from KU Leuven, the Chinese National Scholarship for Graduate Students 2014 and for Undergraduate Students 2008.

Research Interest and Project

Dr. Bian is actively involved in the state-of-art therapeutic drug monitoring to achieve individualized medicine. Her research expertise expends from classic detection techniques (immunoassays) to rapid techniques (lateral flow assays and optical biosensors) in the field of monoclonal antibodies specifically. Her current interest is on micro/nano biosensors for real-time and continuous monitoring of drugs, with an effort to understand how a medicine reacts inside and directly towards a human body. At CenBRAIN, Dr. Bian is currently responsible for two research projects.

  • Rapid optical biosensors for SARS-CoV2 neutralizing antibodies detection in dried blood sot samples Precise monitoring of SARS-CoV2 NAbs is of great importance for evaluating the vaccines safety and investigating the dynamics of immune response and epidemiology of COVID-19. In this project, signal-enhanced bio-layer interferometry (BLI) technique will be integrated with dried blood spot self-sampling to establish an optical fiber biosensor for monitoring of SARS-CoV2 NAbs within approximately 10min. The clinical validity and utility will be evaluated by using real human samples.
  • Towards continuous drug monitoring of anti-epileptic drug Advanced therapeutic drug monitoring (TDM) is an effective tool to improve the precision medicine of anti-epileptic drug (AED), such as carbamazepine, by providing in-time information about an individual's response to therapeutics. At CenBRAIN, advanced TDM for AED will be implemented by competitive ELISA-based optical biosensor and by interdigitated electrodes-based electrical biosensor for rapid test.

Representative publications

[1] Bian S, Zhu B-W, Rong G-G, Sawan M. Towards Wearable and Implantable Continuous Drug Monitoring: A Review. J Pharm Anal, 2021; 11(1):1-14. Cover Paper. LINK
[2] Bian S, Van den Berghe N, Vandersmissen L, et al, "Evaluating an easy sampling method using dried blood spots to determine vedolizumab concentrations", J Pharm Biomed Anal, 2020, 185:113224.
[3] Bian S, Dreesen E, Tang HT, et al, "Antibodies towards vedolizumab appear from the first infusion onwards and disappear over time", Inflamm Bowel Dis, 2017, 23(12):2202-2208.